Fig. 8

Virus replication and hallmark genes in Mx1-deficient mice. A Boxplot of virus gene expression in mock-treated and infected B6-Mx1^r/r and D2-Mx1^r/r mice at days 3 and 5 p.i. Each box shows the results for one mouse sample. Samples are organized by groups, each sample representing a biological replicate (mouse). The boxes show the range of expression values (mean and 25% and 75% quartiles of CPMs) for all virus segments for this mouse. Note that because of some host reads mapping to virus genes and subsequent normalization, virus signals in mock-treated mice are not zero but at background levels. B Boxplot for Mx1 gene expression values in each group of Mx1-deficient mice. Each dot represents the value from a single mouse. Boxes represent the mean and range (25% and 75% quartiles) of normalized log₂ transformed expression values per group. C Numbers of up- and down-regulated DEGs for contrasts between the indicated groups of infected B6-Mx1^−/− and D2-Mx1^−/− and mock-treated mice at days 3 and 5 p.i