Fig. 1

Body weight loss and virus replication. Mice were infected with 2 × 10³ FFU of mouse-adapted PRF virus. A Body weight was recorded as a percent of the starting weight until mice were sacrificed. The plot shows the mean and +/- 1 SEM of the relative body weight for five biological replicates (mice) per group. B Boxplot of virus gene expression in mock-treated and infected B6-Mx1^r/r and D2-Mx1^r/r mice at days 3 and 5 p.i. Each box shows the results for one mouse sample. Samples are organized by groups, each sample representing a biological replicate (mouse). The boxes show the range of expression values (mean and 25% and 75% quartiles of CPMs) for all virus segments for this mouse. C Scatter plot representing the relative body weight (percent of starting body weight) for each mouse related to the virus gene expression (log₂ of the sum of CPMs from all segments) for this mouse. Each mouse is represented by a point. A strong correlation between relative body weight and virus gene expression was observed. Correlation coefficient: -0.67, p-value: 6 × 10⁻⁵