Table 3 Relative mRNA levels of EMT-related genes in CRC
Gene | Frequency of mRNA level changes, % | Median of mRNA level changes, n-fold | |
|---|---|---|---|
↑ increased expression | ↓ decreased expression | ||
TWIST1 | 68 (30/44) | 5 (2/44) | 2.8↑ |
SNAIL1 | 80 (35/44) | 2 (1/44) | 3.3↑ |
SNAIL2 | 11 (5/44) | 20 (9/44) | 1.2↓ |
ZEB1 | 9 (4/44) | 36 (16/44) | 1.5↓ |
ZEB2 | 7 (3/44) | 45 (20/44) | 1.7↓ |
LEF1 | 75 (33/44) | 2 (1/44) | 3.9↑ |
FOXA1 | 7 (3/44) | 52 (23/44) | 2.1↓ |
FOXA2 | 59 (26/44) | 5 (2/44) | 2.5↑ |
CDH1 | 5 (2/44) | 16 (7/44) | 1.3↓ |
STAT1 | 25 (11/44) | 5 (2/44) | 1.4↑ |
BMP2 | 2 (1/44) | 75 (33/44) | 3.2↓ |
BMP5 | 7 (3/44) | 84 (37/44) | 7.6↓ |
VIM | 18 (8/44) | 7 (3/44) | 1.3↑ |
SMAD2 | 0 (0/44) | 11 (5/44) | 1.4↓ |
SMAD3 | 0 (0/44) | 11 (5/44) | 1.2↓ |
SMAD4 | 0 (0/44) | 23 (10/44) | 1.5↓ |
SMAD7 | 0 (0/44) | 43 (19/44) | 1.8↓ |